I-Peptide yikhompawundi ye-organic, ethi iphelelwe ngamanzi kwi-amino acids kwaye iqulethe i-carboxyl kunye namaqela e-amino.Yikhompawundi ye-amphoteric.I-Polypeptide yikhompawundi eyenziwe ngama-amino acids adityaniswe kunye ngamabhondi e-peptide.Yimveliso ephakathi yeprotein hydrolysis.Yenziwe ngokuphelelwa ngamanzi emzimbeni kunye ne-condensation ye-10 ~ 100 i-amino acid molecules, kwaye ubunzima bayo be-molecular bungaphantsi kwe-10000Da.Inokungena kwi-membrane e-semi-permeable kwaye ayigqithiswanga yi-trichloroacetic acid kunye ne-ammonium sulfate, kuquka i-peptides ye-bioactive kunye ne-artificial synthetic peptides.
Amachiza e-Polypeptide abhekisela kwi-polypeptides enemiphumo ethile yonyango ngokusebenzisa i-chemical synthesis, ukuhlanganiswa kwemfuza kunye nokutsalwa kwezilwanyana kunye nezityalo, ezihlulwe ngokukodwa kwii-polypeptides ezingapheliyo (ezifana ne-enkephalin kunye ne-thymosin) kunye nezinye iipolypeptides zangaphandle (ezifana ne-snake venom kunye ne-asilic acid).Ubunzima bemolekyuli obunxulumene namachiza e-polypeptide buphakathi kwamachiza eprotheyini kunye neziyobisi ze-micromolecule, ezinoncedo lwamachiza amancinci kunye namachiza eprotheni.Xa kuthelekiswa neziyobisi ze-micromolecule, amachiza e-polypeptide anomsebenzi ophezulu webhayoloji kunye nezinto ezithile ezinamandla.Xa kuthelekiswa namachiza eprotheyini, amachiza e-polypeptide anozinzo olungcono, ukungazinzi komzimba, ukucoceka okuphezulu kunye neendleko eziphantsi.
I-Polypeptide inokufunxwa ngokuthe ngqo kwaye ngokusebenzayo ngumzimba, kwaye isantya sokufunxa sikhawuleza, kwaye ukufunxa kwepolypeptide kubaluleke kakhulu.Ukongeza, i-peptides ayinakuthwala izondlo kuphela, kodwa iphinde idlulisele ulwazi lweselula ukuyalela imithambo-luvo.Iziyobisi zePolypeptide zineempawu zomsebenzi ophezulu, ukukhetha okuphezulu, ubuthi obuphantsi kunye nobudlelwane obujoliswe kuyo obuphezulu, kodwa kwangaxeshanye, nabo baneengxaki zesiqingatha sobomi obufutshane, ukunyanzeliswa kwe-cell membrane kunye nendlela enye yokulawula.
Ngokujonga iintsilelo zamachiza e-polypeptide, abaphandi benze iinzame ezingagungqiyo kwindlela yokuphucula i-peptides ukuphucula ukufumaneka kweziyobisi ze-polypeptide.Ukuhamba ngebhayisikile kweepeptides yenye yeendlela zokwandisa iipeptides, kwaye uphuhliso lweepeptides ze-cyclic lwazise amayeza epolypeptide ukusa.Iipeptide ze-cyclic ziluncedo kwiyeza ngenxa yokuzinza kwazo kakuhle kwe-metabolic, ukukhetha kunye nokuhambelana, ukunyanzeliswa kwe-cell membrane kunye nokufumaneka komlomo.Iipeptide ze-cyclic zinemisebenzi yebhayoloji efana ne-anti-cancer, anti-infection, anti-fungus kunye ne-anti-virus, kwaye zithembisa kakhulu iimolekyuli zamachiza.Kwiminyaka yakutshanje, amachiza e-cyclic peptide atsale umdla omkhulu, kwaye iinkampani ezixuba amayeza zilandele umkhwa wophuhliso lwamachiza olutsha kwaye zenza imikhondo yamachiza e-cyclic peptide enye emva kwenye.
UGqr. Chen Shiyu ovela kwi-Shanghai Institute of Pharmacology, i-Academy yaseShayina yeSayensi yazisa amachiza e-peptide e-cyclic evunyiweyo ukusuka kwi-2001 ukuya kwi-2021 kumachiza e-peptide e-cyclic evunyiweyo kumachiza amabini okugqibela.Kwiminyaka engama-20 edlulileyo, kukho iintlobo ezili-18 zamachiza e-cyclic peptide kwimarike, apho inani le-cyclic peptides elisebenza kwi-cell wall synthesis kunye ne-β-1,3- glucanase ekujoliswe kuyo lelona likhulu, lineentlobo ezi-3 inye.Amachiza avunyiweyo e-cyclic peptide agubungela i-anti-infection, i-endocrine, inkqubo yokugaya ukutya, i-metabolism, i-tumor / i-immunity kunye ne-system ye-nervous system, phakathi kwayo i-anti-infection kunye ne-endocrine cyclic peptide drugs account for 66.7%.Ngokubhekiselele kwiintlobo zebhayisikile, kukho amachiza amaninzi e-cyclic peptide ahamba ngebhayisekile ngamabhondi e-disulfide kunye nebhayisekile ngamabhondi e-amide, kunye ne-7 kunye ne-6 yamachiza avunyiweyo ngokulandelelanayo.
Ixesha lokuposa: Sep-18-2023