Kwijusi yesisu somntu, i-BPC 157 izinzile ngaphezu kweeyure ze-24, kwaye ngaloo ndlela ine-bioavailability yomlomo (ehlala inikezelwa yedwa) kunye nemiphumo enenzuzo kuyo yonke i-gastrointestinal tract.Lo ngumahluko obalulekileyo kwi-peptides enye esemgangathweni, esebenza ngokuxhomekeke ekongezwe kwe-carrier okanye zitshatyalaliswe ngokukhawuleza kwijusi yesisu somntu.Ngenxa yoko, i-BPC ezinzileyo ye-157 icetyiswa ukuba ibe ngumlamli we-cytoprotection kaRobert, egcina ingqibelelo ogastrointestinal mucosa.Sicebisa ukuba igalelo le-BPC 157 kwi-cytoprotection kaRobert - oko kukuthi, ukukwazi ukuchasana nezilonda ezisisiseko ezibangelwa butywala, apho uRobert wabiza ngokuba yi-cytoprotection - kunye nokukwazi ukuchasana nezilonda ezivela kunxibelelwano olubi ngqo lwearhente enobungozi kunye neseli. imele unxibelelwano lweperipheral phakathi kwamathumbu kunye ne-axis yobuchopho.
I-Perovic ibike ukuba i-BPC 157 inempembelelo ephawulekayo yonyango ephathelele ukubuyiswa kweegundane kunye nokulimala komgogodla kunye nokukhubazeka komsila (i-1-minute compression injury of the sacrocaudal spinal cord [S2-Co1]).Ngokukodwa, ulawulo olulodwa lwe-intraperitoneal BPC 157 kwimizuzu eyi-10 emva kokulimala iphikisana nemiphumo emibi.Ngokwahlukileyo, ukulimala kwentambo yomgogodla kunye nomsila wokukhubazeka kuqhubeka kwiigundane ezingaphendulwanga, iintsuku ezihlolwe, iiveki, iinyanga, kunye nonyaka emva kokulimala.Inqaku, i-BPC 157 ithoba umonakalo odla ngokubangelwa .Ngaloo ndlela, unyango lwe-BPC 157 luphumela ekusebenzeni okucacileyo, i-microscopic, kunye ne-electrophysiologic recovery.
Inqaku, kwiigundane ezinokulimala komgogodla, kukho ukuphindaphinda okusisigxina.Emva kokuba i-BPC 157 ilawulwa ngemizuzu eyi-10 emva kokulimala, kukho ukukhuselwa okuqhubekayo kwaye akukho kuphazamiseka okubangelwa yintambo yomgogodla ozenzekelayo kwakhona.Zonke ukulimala kwentambo yomgogodla ngokukhawuleza kukhupha igazi, kunye nokufa okulandelayo kwee-neurons kunye ne-oligodendrocytes.
Ke, kucingelwa ukuba i-hemostasis yokuqala inokuba luncedo kwaye incede ukubuyiswa kokusebenza emva kokuphazamiseka kwentambo yomgogodla kwiimpuku.Nangona kunjalo, umphumo owenziwe yi-BPC 157 unokuthi uhluke kwimpembelelo elula ye-hemostatic enokuthi ithintele ukwenzakala kwentambo yomgogodla, kuba i-BPC 157 iphucula ngokuphawulekayo umsebenzi we-thrombocyte kwiimpuku ngaphandle kokuchaphazela izinto ezidibeneyo.Ngexesha lokubuyisela ekulimaleni komgogodla, i-BPC 157 ikhusela ngokuthe ngqo i-endothelium, inciphisa ukuphazamiseka kwe-vascular occlusion ye-peripheral, isebenze ngokukhawuleza ezinye iindlela ze-bypass, kwaye iphikisana ne-syndromes ye-venous occlusion-induced syndromes.Ngaloo ndlela, kucingelwa ukuba kukho igalelo elikhulu le-venous kuxinzelelo lwe-spinal cord, kucingelwa ukuba ukuhamba kwegazi okuhlaziyiweyo okuxutywe yi-BPC 157 ngokungathandabuzekiyo kunokufaka isandla kwisiphumo sokubuyisela ngokukhawuleza.Ngaphezu koko, ngokuqwalasela ukuba i-BPC 157 ikhuthaza ukuphindaphinda ngokusisigxina emva kokunyanzeliswa kwentambo yomgogodla, kufuneka kuqatshelwe ukuba xa i-BPC 157 inikezelwa ngexesha lokuphindaphinda, iphikisana ne-stroke ebangelwa ukubethelwa kwe-bilateral ye-arteries ye-carotid eqhelekileyo.I-BPC 157 isombulula umonakalo we-neuronal kwaye ikhusela imemori, i-locomotor, kunye nokusilela kokulungelelanisa.I-BPC 157 ngokucacileyo yenza ezi ziphumo ngokutshintsha ukubonakaliswa kofuzo kwihippocampus.
Ukuqukumbela, i-BPC 157 inemiphumo emihle kwi-stroke, i-schizophrenia, kunye nokulimala kwentambo yomgogodla.
Abaphandi baye babonisa ngokungaguqukiyo ukuba i-BPC 157 ineempembelelo ezininzi eziluncedo kuwo wonke umzimba.Akukho sizathu sokubonisa ukuba izibonelelo ze-BPC 157 zilinganiselwe ngokusemthethweni kweemodeli ezisetyenzisiweyo kunye / okanye ukulinganiselwa kwendlela.Ngokwenene, sinokuxoxa ukuba ukusebenza, ukusetyenziswa lula, iprofayili ekhuselekileyo yeklinikhi kunye nendlela ye-BPC 157 imele enye indlela, enokuthi ibe yimpumelelo, isikhokelo sonyango lwexesha elizayo kwiimeko ze-neurological.Ngoko ke, izifundo ezongezelelweyo ziyafuneka ukucacisa ukuba unyango olunokubakho lwe-BPC 157 luza kujongana njani nendlela yokwenza izinto ezibandakanya iindawo ezininzi ze-subcellular kwi-CNS.Impembelelo kumsebenzi wezinto ezininzi, ukuba azikho zonke, iinkqubo ze-neuronal kwi-molecular, cellular, kunye ne-systemic level kufuneka zihlolwe.Enye i-visceral repetitive relay ye-CNS okanye amalungu e-circumventricular, enye yemimandla embalwa ebuchotsheni ngaphandle komqobo we-blood-brain, yindlela eyaziwayo apho i-peptide elawulwa ngokwenkqubo inokusebenzisa isiphumo esisembindini.Ngaloo ndlela, kufuneka isebenze ngaphakathi kwe-axis ye-gut-brain, kungakhathaliseki ukuba esi senzo sithe ngqo okanye singathanga ngqo.
